Premium
Squaramide‐Catalyzed Enantioselective Michael Addition of Diphenyl Phosphite to Nitroalkenes
Author(s) -
Zhu Ye,
Malerich Jeremiah P.,
Rawal Viresh H.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904779
Subject(s) - squaramide , enantioselective synthesis , michael reaction , catalysis , chemistry , nitro , organic chemistry , organocatalysis , alkyl
Michael's a square : An easily prepared squaramide catalyst that promotes the highly enantioselective Michael addition reaction of diphenyl phosphite to a range of nitroalkenes is described. This method leads to chiral β‐nitro phosphonates, which are precursors to biologically active β‐amino phosphonic acids.