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Cortistatin A is a High‐Affinity Ligand of Protein Kinases ROCK, CDK8, and CDK11
Author(s) -
Cee Victor J.,
Chen David Y.K.,
Lee Matthew R.,
Nicolaou K. C.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904778
Subject(s) - kinase , cyclin , cyclin dependent kinase 8 , ligand (biochemistry) , cyclin dependent kinase complex , cyclin dependent kinase , chemistry , microbiology and biotechnology , computational biology , protein kinase a , biology , biochemistry , gene , cyclin dependent kinase 2 , receptor , cell cycle , notch signaling pathway
Antiproliferative alkaloid : Cortistatin A is a high‐affinity ligand for a small set of protein kinases including Rho‐associated, coiled‐coil‐containing protein kinase (ROCK), cyclin‐dependent kinase 8 (CDK8), and cyclin‐dependent kinase 11 (CDK11). Models of cortistatin A bound to a crystallographic structure of ROCK (see picture) and a homology model of CDK8 are presented.