Cortistatin A is a High‐Affinity Ligand of Protein Kinases ROCK, CDK8, and CDK11 | Zendy

Cee Victor J. | Zendy; Chen David Y.K. | Zendy; Lee Matthew R. | Zendy; Nicolaou K. C. | Zendy

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Cortistatin A is a High‐Affinity Ligand of Protein Kinases ROCK, CDK8, and CDK11

Author(s) -

Cee Victor J.,

Chen David Y.K.,

Lee Matthew R.,

Nicolaou K. C.

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200904778

Subject(s) - kinase , cyclin , cyclin dependent kinase 8 , ligand (biochemistry) , cyclin dependent kinase complex , cyclin dependent kinase , chemistry , microbiology and biotechnology , computational biology , protein kinase a , biology , biochemistry , gene , cyclin dependent kinase 2 , receptor , cell cycle , notch signaling pathway

Antiproliferative alkaloid : Cortistatin A is a high‐affinity ligand for a small set of protein kinases including Rho‐associated, coiled‐coil‐containing protein kinase (ROCK), cyclin‐dependent kinase 8 (CDK8), and cyclin‐dependent kinase 11 (CDK11). Models of cortistatin A bound to a crystallographic structure of ROCK (see picture) and a homology model of CDK8 are presented.

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