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Copper as a Powerful Catalyst in the Direct Alkynylation of Azoles
Author(s) -
Besselièvre François,
Piguel Sandrine
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904776
Subject(s) - sonogashira coupling , alkynylation , catalysis , scheme (mathematics) , chemistry , computer science , copper , combinatorial chemistry , world wide web , palladium , organic chemistry , mathematics , mathematical analysis
Copper‐bottomed catalysis! The direct alkynylation of azoles through a copper‐based CH bond activation, using alkynylbromides as the coupling partner, has been developed (see scheme). The method is very rapid, is functional‐group tolerant, and provides a straightforward entry to diverse alkynyl heterocycles that is complementary to the Sonogashira reaction.