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Construction of Fused Heterocyclic Architectures by Formal [4+1]/[3+2] Cycloaddition Cascade of Sulfur Ylides and Nitroolefins
Author(s) -
Lu LiangQiu,
Li Fang,
An Jing,
Zhang JiJi,
An XiaoLei,
Hua QiuLin,
Xiao WenJing
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904766
Subject(s) - alkene , cycloaddition , cascade , sulfur , chemistry , combinatorial chemistry , organic chemistry , computer science , catalysis , chromatography
Under control : A formal [4+1]/[3+2] cycloaddition cascade of sulfur ylides and alkene‐tethered nitroolefins has been developed, and provides an efficient synthesis of fused polycyclic heterocyclic compounds in good to excellent overall yields with excellent diastereocontrol (see scheme). A catalytic asymmetric variant of this reaction has also been disclosed.