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A Rigid Helical Peptide Axle for a [2]Rotaxane Molecular Machine
Author(s) -
Moretto Alessandro,
Menegazzo Ileana,
Crisma Marco,
Shotton Elizabeth J.,
Nowell Harriott,
Mammi Stefano,
Toniolo Claudio
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904749
Subject(s) - rotaxane , axle , molecular machine , molecular motor , translation (biology) , rotation (mathematics) , helix (gastropod) , spinning , construct (python library) , crystallography , sma* , computer science , materials science , chemistry , nanotechnology , mechanical engineering , artificial intelligence , engineering , gene , biology , polymer chemistry , biochemistry , algorithm , supramolecular chemistry , snail , ecology , programming language , messenger rna , crystal structure
Spinning around? A series of peptido[2]rotaxanes have been designed which contain a rigid helix as a significant part of their axle. One such rotaxane has been used to construct a reversible molecular device, in which, by virtue of the size of the inner cavity of the wheel relative to the outer diameter of the peptide helix, a rotation of the wheel might occur concomitantly with its translation along the axle (see picture).