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Activation of Allylic CF bonds: Palladium‐Catalyzed Allylic Amination of 3,3‐Difluoropropenes
Author(s) -
Pigeon Xavier,
Bergeron Maxime,
Barabé Francis,
Dubé Pascal,
Frost Heather N.,
Paquin JeanFrançois
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904747
Subject(s) - allylic rearrangement , palladium , amination , catalysis , chemistry , combinatorial chemistry , medicinal chemistry , stereochemistry , computer science , organic chemistry
Lose one, keep one! A wide range of cyclic and acyclic β‐aminofluoroalkenes are prepared by the title reaction. The key fluorinated palladium π‐allyl intermediate is generated using a catalytic allylic CF bond activation.