Reduction/Dissolution of a β‐MnOOH Nanophase in the Ferritin Cavity To Yield a Highly Sensitive, Biologically Compatible Magnetic Resonance Imaging Agent | Zendy

Kálmán Ferenc Krisztián | Zendy; GeninattiCrich Simonetta | Zendy; Aime Silvio | Zendy

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Reduction/Dissolution of a β‐MnOOH Nanophase in the Ferritin Cavity To Yield a Highly Sensitive, Biologically Compatible Magnetic Resonance Imaging Agent

Author(s) -

Kálmán Ferenc Krisztián,

GeninattiCrich Simonetta,

Aime Silvio

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200904731

Subject(s) - nanocarriers , amphiphile , micelle , ferritin , magnetic resonance imaging , dissolution , gadolinium , liposome , chemistry , materials science , reducing agent , mri contrast agent , nanotechnology , nanoparticle , nuclear magnetic resonance , biochemistry , organic chemistry , aqueous solution , copolymer , polymer , medicine , physics , radiology

A manganese‐based contrast agent for magnetic resonance imaging has been obtained by partial reduction/dissolution of solid β‐MnOOH inside the cavity of apoferritin (see scheme). The resulting nanocarriers contain up to 300–400 Mn II aqua ions and have a remarkable relaxivity of 4000–7000 m M −1 s −1 per apoferritin unit.

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