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Total Synthesis of TK‐57 ‐ 164A, Isariotin F, and Their Putative Progenitor Isariotin E
Author(s) -
Cha Jacob Y.,
Huang Yaodong,
Pettus Thomas R. R.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904716
Subject(s) - simple (philosophy) , computer science , foundation (evidence) , world wide web , information retrieval , philosophy , political science , epistemology , law
Keeping it simple : A simple strategy for the total synthesis of three complex natural products has been developed, while also confirming the putative generation of 1 and 2 from 3 . The benefits of a simple dissymmetric 2,5‐cyclohexadienone are illustrated and provide the foundation for rapid diastereoselective functionalization leading to the first total synthesis of these compounds.