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Enantiodivergent Organocascade Reactions
Author(s) -
Westermann Bernhard,
Ayaz Muhammad,
van Berkel Sander S.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904638
Subject(s) - iminium , enamine , organocatalysis , chemistry , catalysis , synchronizing , stereochemistry , computer science , enantioselective synthesis , organic chemistry , telecommunications , transmission (telecommunications)
Synchronizing organocatalysis! By targeting structural and stereochemical complexity with organocascade reactions, distinct catalysts can form molecular frameworks in an enantiodivergent way. This goal was elegantly achieved for the asymmetric synthesis of quaternary carbon centers by two complementary routes employing cascades of either enamine or iminium catalysis (see scheme; En=enamine activation, Im=iminium activation).