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A Multinuclear Coordination System of L ‐Cysteine and L ‐Penicillamine That Induce Opposite Chiralities at Metal Centers
Author(s) -
Sameshima Yuko,
Yoshinari Nobuto,
Tsuge Kiyoshi,
IgashiraKamiyama Asako,
Konno Takumi
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904635
Subject(s) - penicillamine , intramolecular force , steric effects , chemistry , cysteine , coordination complex , stereochemistry , metal , hydrogen bond , crystallography , molecule , biochemistry , organic chemistry , enzyme
Same but different : L ‐Cysteine ( L ‐cys) and L ‐penicillamine ( L ‐pen) ligands are incorporated in similar pentanuclear Au I 3 M 2 (M=Ni II , Co III ) structures with, however, opposite stereochemical configurations. This phenomenon is explained in terms of intramolecular hydrogen bonding and steric interactions, which may provide insight into why D ‐penicillamine behaves like L ‐cysteine in nature.