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Stereoselective Synthesis of β‐Chlorovinyl Ketones and Arenes by the Catalytic Addition of Acid Chlorides to Alkynes
Author(s) -
Gooßen Lukas J.,
Rodríguez Nuria,
Gooßen Käthe
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904615
Subject(s) - chemistry , catalysis , iridium , decarbonylation , stereoselectivity , medicinal chemistry , ligand (biochemistry) , biphenyl , organic chemistry , biochemistry , receptor
New cats, new tricks : Complementary iridium catalysts enable the Z ‐selective catalytic addition of acid chlorides to alkynes. Depending on the ligand, the reaction proceeds with or without decarbonylation to give β‐chlorovinyl‐substituted arenes or ketones: useful intermediates for the synthesis of heterocycles. cod=cyclooctadiene, IPr=1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene), RuPhos=2‐dicyclohexylphosphanyl‐2′,6′‐diisopropoxy‐1,1′‐biphenyl.