Premium
Total Synthesis of Zoanthenol
Author(s) -
Takahashi Yu,
Yoshimura Fumihiko,
Tanino Keiji,
Miyashita Masaaki
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904537
Subject(s) - total synthesis , stereochemistry , intramolecular force , chemistry , stereoselectivity , ring (chemistry) , biological activity , alkaloid , amino acid , combinatorial chemistry , biochemistry , organic chemistry , in vitro , catalysis
Reaching home plate : The first total synthesis of zoanthenol, an aromatic member of the zoanthamine alkaloid family with potent anti‐platelet activity for human platelet aggregation, has been achieved using an intermediate in the total synthesis of norzoanthamine. The key step involves a Brønsted acid‐promoted isoaromatization in the AB ring system to install the crucial aromatic ring.