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Catalytic Enantioselective Olefin Metathesis in Natural Product Synthesis. Chiral Metal‐Based Complexes that Deliver High Enantioselectivity and More
Author(s) -
Hoveyda Amir H.,
Malcolmson Steven J.,
Meek Simon J.,
Zhugralin Adil R.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904491
Subject(s) - enantioselective synthesis , enantiomer , olefin fiber , catalysis , olefin metathesis , metathesis , stereoselectivity , combinatorial chemistry , chemistry , natural product , organic chemistry , salt metathesis reaction , polymerization , polymer
Chiral olefin metathesis catalysts enable chemists to access enantiomerically enriched small molecules with high efficiency; synthesis schemes involving such complexes can be substantially more concise than those that would involve enantiomerically pure substrates and achiral Mo alkylidenes or Ru‐based carbenes. The scope of research towards design and development of chiral catalysts is not limited to discovery of complexes that are merely the chiral versions of the related achiral variants. A chiral olefin metathesis catalyst, in addition to furnishing products of high enantiomeric purity, can offer levels of efficiency, product selectivity and/or olefin stereoselectivity that are unavailable through the achiral variants. Such positive attributes of chiral catalysts (whether utilized in racemic or enantiomerically enriched form) should be considered as general, applicable to other classes of transformations.