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Asymmetric Synthesis of β‐Alkynyl Aldehydes by Rhodium‐Catalyzed Conjugate Alkynylation
Author(s) -
Nishimura Takahiro,
Sawano Takahiro,
Hayashi Tamio
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904486
Subject(s) - alkynylation , conjugate , acetylene , rhodium , scheme (mathematics) , catalysis , chemistry , combinatorial chemistry , enantioselective synthesis , point (geometry) , computer science , organic chemistry , mathematics , mathematical analysis , geometry
To the point : The rhodium‐catalyzed asymmetric conjugate alkynylation of α,β‐unsaturated aldehydes with triisopropylsilyl acetylene proceeded efficiently in methanol to give the β‐alkynyl aldehydes in high yields with high enantioselectivity (see Scheme).