Premium
Mechanistic Studies on the Reaction between R 2 N‐NONOates and Aquacobalamin: Evidence for Direct Transfer of a Nitroxyl Group from R 2 N‐NONOates to Cobalt(III) Centers
Author(s) -
Hassanin Hanaa A.,
Hannibal Luciana,
Jacobsen Donald W.,
ElShahat Mohamed F.,
Hamza Mohamed S. A.,
Brasch Nicola E.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904360
Subject(s) - nitroxyl , chemistry , transfer (computing) , cobalamin , decomposition , group (periodic table) , stereochemistry , organic chemistry , computer science , biochemistry , parallel computing , vitamin b12
Tales of the unexpected : Transfer of a nitroxyl group from R 2 N‐NONOates to aquacobalamin to form nitroxylcobalamin does not proceed via H + ‐catalyzed R 2 N‐NONOate decomposition, but instead occurs via a probable NONOate‐cobalamin intermediate (see scheme; r.d.s.=rate‐determining step).