Mechanistic Studies on the Reaction between R 2 N‐NONOates and Aquacobalamin: Evidence for Direct Transfer of a Nitroxyl Group from R 2 N‐NONOates to Cobalt(III) Centers | Zendy

Hassanin Hanaa A. | Zendy; Hannibal Luciana | Zendy; Jacobsen Donald W. | Zendy; ElShahat Mohamed F. | Zendy; Hamza Mohamed S. A. | Zendy; Brasch Nicola E. | Zendy

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Mechanistic Studies on the Reaction between R 2 N‐NONOates and Aquacobalamin: Evidence for Direct Transfer of a Nitroxyl Group from R 2 N‐NONOates to Cobalt(III) Centers

Author(s) -

Hassanin Hanaa A.,

Hannibal Luciana,

Jacobsen Donald W.,

ElShahat Mohamed F.,

Hamza Mohamed S. A.,

Brasch Nicola E.

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200904360

Subject(s) - nitroxyl , chemistry , transfer (computing) , cobalamin , decomposition , group (periodic table) , stereochemistry , organic chemistry , computer science , biochemistry , parallel computing , vitamin b12

Tales of the unexpected : Transfer of a nitroxyl group from R 2 N‐NONOates to aquacobalamin to form nitroxylcobalamin does not proceed via H + ‐catalyzed R 2 N‐NONOate decomposition, but instead occurs via a probable NONOate‐cobalamin intermediate (see scheme; r.d.s.=rate‐determining step).

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