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Isothiourea‐Catalyzed Enantioselective Carboxy Group Transfer
Author(s) -
Joannesse Caroline,
Johnston Craig P.,
Concellón Carmen,
Simal Carmen,
Philp Douglas,
Smith Andrew D.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904333
Subject(s) - enantioselective synthesis , group (periodic table) , catalysis , stereochemistry , chemistry , transfer (computing) , combinatorial chemistry , organic chemistry , computer science , parallel computing
Transferable skills : Enantiomerically pure isothioureas promote the O‐ to C‐carboxyl group transfer of oxazolyl carbonates with excellent levels of enantiocontrol (see scheme). The origin of the enantioselectivity of this process was probed mechanistically and rationalized computationally.