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Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells
Author(s) -
Li YuLing,
Zhu Li,
Liu Zhaozhong,
Cheng Ru,
Meng Fenghua,
Cui JingHao,
Ji ShunJun,
Zhong Zhiyuan
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904260
Subject(s) - doxorubicin , intracellular , dextran , nanoparticle , in vitro , tumor cells , drug delivery , chemistry , cancer cell , nanotechnology , biophysics , computer science , cancer research , cancer , materials science , biochemistry , biology , chemotherapy , genetics
Getting in there : Efficient intracellular delivery of anticancer drugs is achieved by using reversibly cross‐linked dextran nanoparticles, which are rapidly destabilized under reductive environments that mimic those of the intracellular compartments. These nanoparticles show high drug loading efficiency and reduction‐triggered release of doxorubicin in vitro as well as inside tumor cells, particularly to the cell nucleus (see scheme).