Mapping the Landscape of Potentially Primordial Informational Oligomers: Oligo‐dipeptides Tagged with Orotic Acid Derivatives as Recognition Elements | Zendy

Zhang Xuejun | Zendy; Krishnamurthy Ramanarayanan | Zendy

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Mapping the Landscape of Potentially Primordial Informational Oligomers: Oligo‐dipeptides Tagged with Orotic Acid Derivatives as Recognition Elements

Author(s) -

Zhang Xuejun,

Krishnamurthy Ramanarayanan

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200904188

Subject(s) - pairing , orotic acid , base pair , base (topology) , chemistry , value (mathematics) , stereochemistry , combinatorial chemistry , biochemistry , physics , computer science , mathematics , dna , machine learning , quantum mechanics , mathematical analysis , superconductivity

Partner up! Base‐pairing properties of oligo‐dipeptides tagged with orotic acid and its 2,4‐diamino counterpart (see structure) are found to be consistent with previously observed correlations between Δp K a values and the pairing strength of complementary bases. The combined results provide a general justification for anticipating the base‐pairing propensity of a recognition element based on its p K a value and the pH of the medium.

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