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Mapping the Landscape of Potentially Primordial Informational Oligomers: Oligo‐dipeptides Tagged with Orotic Acid Derivatives as Recognition Elements
Author(s) -
Zhang Xuejun,
Krishnamurthy Ramanarayanan
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904188
Subject(s) - pairing , orotic acid , base pair , base (topology) , chemistry , value (mathematics) , stereochemistry , combinatorial chemistry , biochemistry , physics , computer science , mathematics , dna , machine learning , quantum mechanics , mathematical analysis , superconductivity
Partner up! Base‐pairing properties of oligo‐dipeptides tagged with orotic acid and its 2,4‐diamino counterpart (see structure) are found to be consistent with previously observed correlations between Δp K a values and the pairing strength of complementary bases. The combined results provide a general justification for anticipating the base‐pairing propensity of a recognition element based on its p K a value and the pH of the medium.