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Templated Ligand Environments for the Selective Incorporation of Different Metals into DNA
Author(s) -
Yang Hua,
Rys Andrzej Z.,
McLaughlin Christopher K.,
Sleiman Hanadi F.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904186
Subject(s) - terpyridine , phenanthroline , ligand (biochemistry) , template , dna , metal , chemistry , combinatorial chemistry , redox , oxidation state , nanotechnology , materials science , crystallography , inorganic chemistry , organic chemistry , biochemistry , receptor
Each to his own : DNA templates the formation of bis(terpyridine), bis(phenanthroline), and terpyridine:phenanthroline ligand environments, which strongly bind Fe II , Cu I , and Cu II (see picture), respectively, to generate highly stable metal–DNA complexes. When a metal is placed in the “incorrect” environment, it can spontaneously adjust its redox state, be displaced by another metal, or reorganize the coordination site to create a more favored complex.