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Externally Triggered Glass Transition Switch for Localized On‐Demand Drug Delivery
Author(s) -
Keurentjes Jos T. F.,
Kemmere Maartje F.,
Bruinewoud Henny,
Vertommen Micky A. M. E.,
Rovers Stefan A.,
Hoogenboom Richard,
Stemkens Léon F. S.,
Péters Fabiènne L. A. M. A.,
Tielen Naomi J. C.,
van Asseldonk Dirk T. A.,
Gabriel Anne F.,
Joosten Elbert A.,
Marcus Marco A. E.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904172
Subject(s) - drug delivery , glass transition , polymer , on demand , ibuprofen , drug , materials science , nanotechnology , chemical physics , chemical engineering , thermal diffusivity , layer (electronics) , transition (genetics) , chemistry , composite material , thermodynamics , computer science , pharmacology , medicine , multimedia , physics , engineering , biochemistry , gene
I want a new drug dose : External on‐demand laser triggering is used in a drug‐delivery concept, with on/off ratios in excess of 1000/1. The switching mechanism involves the glass transition of hydrophobic polymers with a large change in diffusivity. Formation of a glassy surface layer of the implant in the off state plays a key role, resulting in negligible off‐release. (Picture: data points indicate ibuprofen concentration).