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Siamese Depsipeptides: Constrained Bicyclic Architectures
Author(s) -
RuizRodríguez Javier,
Spengler Jan,
Albericio Fernando
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904135
Subject(s) - depsipeptide , class (philosophy) , computer science , combinatorial chemistry , chemistry , stereochemistry , artificial intelligence
The first members of a new class of depsipeptides with tartaric acid as the core unit, called Siamese depsipeptides, are described. These compounds were synthesized from a branched precursor in only one cyclization step. The structural manipulation of a natural bioactive depsipeptide (sansalvamide A) gives analogues with greater activity, and thereby provides additional information on structure–activity relationships (see structures).