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Highly Efficient “Grafting onto” a Polypeptide Backbone Using Click Chemistry
Author(s) -
Engler Amanda C.,
Lee Hyungil,
Hammond Paula T.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904070
Subject(s) - propargyl , click chemistry , ethylene glycol , grafting , polymerization , peg ratio , polymer chemistry , chemistry , ring opening polymerization , combinatorial chemistry , polymer science , organic chemistry , polymer , catalysis , finance , economics
“Clicked” into place : Densely grafted poly(γ‐propargyl‐ L ‐glutamate)‐g‐poly(ethylene glycol) polypeptides have been synthesized by combining ring‐opening polymerization of N ‐carboxyanhydrides with click chemistry. Various lengths of poly(ethylene glycol) (PEG) side chains (750 g mol −1 to 5000 g mol −1 ) were attached to a rigid α‐helical poly(γ‐propargyl‐ L ‐glutamate); extremely high grafting efficiencies of over 96 % were achieved.