Highly Efficient “Grafting onto” a Polypeptide Backbone Using Click Chemistry | Zendy

Engler Amanda C. | Zendy; Lee Hyungil | Zendy; Hammond Paula T. | Zendy

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Highly Efficient “Grafting onto” a Polypeptide Backbone Using Click Chemistry

Author(s) -

Engler Amanda C.,

Lee Hyungil,

Hammond Paula T.

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200904070

Subject(s) - propargyl , click chemistry , ethylene glycol , grafting , polymerization , peg ratio , polymer chemistry , chemistry , ring opening polymerization , combinatorial chemistry , polymer science , organic chemistry , polymer , catalysis , finance , economics

“Clicked” into place : Densely grafted poly(γ‐propargyl‐ L ‐glutamate)‐g‐poly(ethylene glycol) polypeptides have been synthesized by combining ring‐opening polymerization of N ‐carboxyanhydrides with click chemistry. Various lengths of poly(ethylene glycol) (PEG) side chains (750 g mol −1 to 5000 g mol −1 ) were attached to a rigid α‐helical poly(γ‐propargyl‐ L ‐glutamate); extremely high grafting efficiencies of over 96 % were achieved.

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