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α‐Alkylation of Carbonyl Compounds by Direct Addition of Alcohols to Enol Acetates
Author(s) -
Nishimoto Yoshihiro,
Onishi Yoshiharu,
Yasuda Makoto,
Baba Akio
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200904069
Subject(s) - enol , alkylation , chemistry , organic chemistry , catalysis , key (lock) , computer science , computer security
A practical α‐alkylation of ketones and aldehydes has been achieved by the direct addition of alcohols to enol acetates. The moderate Lewis acidity of InI 3 , GaBr 3 , and FeBr 3 is a key factor in the catalytic cycle, and many different alcohols and enol acetates have been successfully used in this procedure.