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Silver‐Mediated Direct Amination of Benzoxazoles: Tuning the Amino Group Source from Formamides to Parent Amines
Author(s) -
Cho Seung Hwan,
Kim Ji Young,
Lee S. Yunmi,
Chang Sukbok
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903957
Subject(s) - formamides , amination , racemization , chemistry , group (periodic table) , organic chemistry , combinatorial chemistry , catalysis
Going to the source : Formamides or parent amines were used as an amino group source for the silver‐mediated amination of benzoxazoles. Although reactions with formamides proceeded at high temperatures, the direct amination with amines took place under much milder conditions (see scheme). Optically active amino groups could also be installed without racemization.