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Synthesis of Phenol, Aromatic Ether, and Benzofuran Derivatives by Copper‐Catalyzed Hydroxylation of Aryl Halides
Author(s) -
Zhao Dongbing,
Wu Ningjie,
Zhang Shuai,
Xi Peihua,
Su Xiaoyu,
Lan Jingbo,
You Jingsong
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903923
Subject(s) - aryl , hydroxylation , halide , benzofuran , chemistry , domino , organic chemistry , phenol , catalysis , phenols , ether , copper , alkyl , combinatorial chemistry , enzyme
A smooth operator : The copper‐catalyzed synthesis of phenols from aryl halides was carried out under relatively mild reaction conditions. Alkyl aryl ethers and benzofurans could also be prepared smoothly by one‐pot domino protocols based on hydroxylation of aryl iodides (see scheme).