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Consecutive Formation of G‐Quadruplexes in Human Telomeric‐Overhang DNA: A Protective Capping Structure for Telomere Ends
Author(s) -
Xu Yan,
Ishizuka Takumi,
Kurabayashi Kaori,
Komiyama Makoto
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903858
Subject(s) - telomere , nuclease , dna , g quadruplex , superhelix , biology , computational biology , chemistry , microbiology and biotechnology , genetics , dna replication , dna supercoil
The end of the line : Structural studies demonstrate the consecutive formation of G‐quadruplexes in human single‐stranded telomeric‐overhang DNA. A higher‐order DNA G‐quadruplex structure was found to protect DNA double‐strand ends from being recognized as double‐strand breaks and to direct against nuclease hydrolysis, suggesting that the superhelix structure may provide protective “capping” for the telomere ends.