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Direct Transformation of Methyl Arenes to Aryl Nitriles at Room Temperature
Author(s) -
Zhou Wang,
Zhang Liangren,
Jiao Ning
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903838
Subject(s) - aryl , transformation (genetics) , chemistry , combinatorial chemistry , surface modification , medicinal chemistry , organic chemistry , biochemistry , alkyl , gene
Three CH bonds are cleaved in the direct transformation of methyl arenes to aryl nitriles under mild and neutral conditions (see scheme). This new synthetic tool may not only be used to construct synthetically and medicinally important aryl nitriles, it also achieves CH functionalization under mild conditions. PIDA=phenyliodonium diacetate.