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Ca 2+ Induces the Formation of Two Distinct Subpopulations of Group II Intron Molecules
Author(s) -
Steiner Miriam,
Rueda David,
Sigel Roland K. O.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903809
Subject(s) - ribozyme , group ii intron , folding (dsp implementation) , intron , group (periodic table) , molecule , chemistry , computational biology , crystallography , physics , stereochemistry , biology , rna , gene , rna splicing , biochemistry , electrical engineering , engineering , organic chemistry
New wrinkles in folding : In the folding of the D135 ribozyme derived from the group II intron Sc. ai5γ, partial replacement of Mg 2+ with Ca 2+ leads to a division into two distinct subpopulations that are not interchangeable. The picture shows the splitting into the two types together with the single‐molecule FRET states.