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Trends in Organocatalytic Conjugate Addition to Enones: An Efficient Approach to Optically Active Alkynyl, Alkenyl, and Ketone Products
Author(s) -
Paixão Márcio Weber,
Holub Nicole,
Vila Carlos,
Nielsen Martin,
Jørgensen Karl Anker
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903790
Subject(s) - optically active , ketone , conjugate , tandem , chemistry , aryl , alkyl , combinatorial chemistry , organic chemistry , materials science , mathematics , mathematical analysis , composite material
Three in one : Applying an organocatalytic tandem strategy to build a library of optically active alkynyl, alkenyl, and ketone products, starting from cyclic enones and β‐keto sulfones, is shown to be rapid and efficient (see scheme; R=aryl, R′=H or alkyl).
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