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Ferrocenyl Quinone Methides as Strong Antiproliferative Agents: Formation by Metabolic and Chemical Oxidation of Ferrocenyl Phenols
Author(s) -
Hamels Didier,
Dansette Patrick M.,
Hillard Elizabeth A.,
Top Siden,
Vessières Anne,
Herson Patrick,
Jaouen Gérard,
Mansuy Daniel
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903768
Subject(s) - phenols , quinone , chemistry , ferrocene , combinatorial chemistry , redox , organic chemistry , electrochemistry , electrode
Hard on cancer cells : Ferrocenyl quinone methides, potentially cytotoxic species, are formed by metabolic and chemical oxidation of ferrocenyl phenols (see scheme). These species display strong antiproliferative properties.