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Asymmetric Reductive Amination by Combined Brønsted Acid and Transition‐Metal Catalysis
Author(s) -
Klussmann Martin
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903765
Subject(s) - reductive amination , amination , organocatalysis , chemistry , catalysis , protonation , stereoselectivity , transition metal , brønsted–lowry acid–base theory , iridium , combinatorial chemistry , rhodium , enantioselective synthesis , organic chemistry , hydrogen atom , ion , alkyl
The best of both worlds : A combination of organocatalysis and transition‐metal catalysis serve in the highly stereoselective and atom‐economical reductive amination of a broad range of ketones. A chiral Brønsted acid catalyst facilitates the formation of protonated imines in situ and serves as chiral counteranion, while a chiral iridium complex catalyzes the reduction with elemental hydrogen.