Guanidinium‐Modified Phthalocyanines as High‐Affinity G‐Quadruplex Fluorescent Probes and Transcriptional Regulators | Zendy

Alzeer Jawad | Zendy; Vummidi Balayeshwanth R. | Zendy; Roth Phillipe J. C. | Zendy; Luedtke Nathan W. | Zendy

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Guanidinium‐Modified Phthalocyanines as High‐Affinity G‐Quadruplex Fluorescent Probes and Transcriptional Regulators

Author(s) -

Alzeer Jawad,

Vummidi Balayeshwanth R.,

Roth Phillipe J. C.,

Luedtke Nathan W.

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200903685

Subject(s) - g quadruplex , fluorescence , dissociation constant , zinc finger , chemistry , dna , dissociation (chemistry) , transcriptional regulation , zinc , biophysics , binding site , microbiology and biotechnology , biochemistry , receptor , biology , transcription factor , gene , physics , organic chemistry , quantum mechanics

Fluorescence is ON and transcriptional control is OFF when the guanidinium‐modified zinc phthalocyanine Zn‐DIGP binds a G‐quadruplex DNA from the c‐Myc promoter. With an equilibrium dissociation constant K d of less than 2 n M , this interaction is the strongest binding interaction between a G‐quadruplex structure and a small molecule reported to date.

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