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Guanidinium‐Modified Phthalocyanines as High‐Affinity G‐Quadruplex Fluorescent Probes and Transcriptional Regulators
Author(s) -
Alzeer Jawad,
Vummidi Balayeshwanth R.,
Roth Phillipe J. C.,
Luedtke Nathan W.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903685
Subject(s) - g quadruplex , fluorescence , dissociation constant , zinc finger , chemistry , dna , dissociation (chemistry) , transcriptional regulation , zinc , biophysics , binding site , microbiology and biotechnology , biochemistry , receptor , biology , transcription factor , gene , physics , organic chemistry , quantum mechanics
Fluorescence is ON and transcriptional control is OFF when the guanidinium‐modified zinc phthalocyanine Zn‐DIGP binds a G‐quadruplex DNA from the c‐Myc promoter. With an equilibrium dissociation constant K d of less than 2 n M , this interaction is the strongest binding interaction between a G‐quadruplex structure and a small molecule reported to date.