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Tantalum–Amidate Complexes for the Hydroaminoalkylation of Secondary Amines: Enhanced Substrate Scope and Enantioselective Chiral Amine Synthesis
Author(s) -
Eisenberger Patrick,
Ayinla Rashidat O.,
Lauzon Jean Michel P.,
Schafer Laurel L.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903656
Subject(s) - enantioselective synthesis , amine gas treating , substrate (aquarium) , chemistry , tantalum , scope (computer science) , combinatorial chemistry , organic chemistry , catalysis , computer science , biology , ecology , programming language
Tantalizing reactivity : New mono‐ and bis(amidate)–tantalum complexes have been prepared, characterized, and used for the catalytic α‐alkylation of secondary amines (see scheme). Spontaneous β‐hydrogen abstraction is observed to give a fully characterized example of the first catalytically active tantallaaziridine complex.