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Coencapsulation of Arsenic‐ and Platinum‐based Drugs for Targeted Cancer Treatment
Author(s) -
Chen Haimei,
Pazicni Samuel,
Krett Nancy L.,
Ahn Richard W.,
PennerHahn James E.,
Rosen Steven T.,
O'Halloran Thomas V.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903655
Subject(s) - arsenic , platinum , computer science , nanotechnology , combinatorial chemistry , chemistry , materials science , biochemistry , organic chemistry , catalysis
Two in one : A novel strategy for efficiently coencapsulating both arsenic‐ and platinum‐based drugs into 100 nm‐scale liposomes (NBs) relies on the formation of Pt II –As III adducts. This co‐loaded system presents a robust platform for further modification with targeting ligands and affords a method of improving the therapeutic efficacy of anticancer agents.