Coencapsulation of Arsenic‐ and Platinum‐based Drugs for Targeted Cancer Treatment | Zendy

Chen Haimei | Zendy; Pazicni Samuel | Zendy; Krett Nancy L. | Zendy; Ahn Richard W. | Zendy; PennerHahn James E. | Zendy; Rosen Steven T. | Zendy; O'Halloran Thomas V. | Zendy

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Coencapsulation of Arsenic‐ and Platinum‐based Drugs for Targeted Cancer Treatment

Author(s) -

Chen Haimei,

Pazicni Samuel,

Krett Nancy L.,

Ahn Richard W.,

PennerHahn James E.,

Rosen Steven T.,

O'Halloran Thomas V.

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200903655

Subject(s) - arsenic , platinum , computer science , nanotechnology , combinatorial chemistry , chemistry , materials science , biochemistry , organic chemistry , catalysis

Two in one : A novel strategy for efficiently coencapsulating both arsenic‐ and platinum‐based drugs into 100 nm‐scale liposomes (NBs) relies on the formation of Pt II –As III adducts. This co‐loaded system presents a robust platform for further modification with targeting ligands and affords a method of improving the therapeutic efficacy of anticancer agents.

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