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First Regio‐ and Enantioselective Chromium‐Catalyzed Homoallenylation of Aldehydes
Author(s) -
Coeffard Vincent,
Aylward Miriam,
Guiry Patrick J.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903647
Subject(s) - enantioselective synthesis , oxazoline , catalysis , chromium , aryl , alkyl , chemistry , chiral ligand , ligand (biochemistry) , regioselectivity , organic chemistry , combinatorial chemistry , receptor , biochemistry
Game, set, and match : The first regio‐ and enantioselective version of the title reaction is described. The chiral catalyst prepared in situ from CrCl 3 and a non‐ C 2 ‐symmetric bis(oxazoline) ligand 1 affords the valuable chiral β‐allenols regioselectively in good yields with excellent ee values. R=aryl, alkyl.