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A Very Simple Copper‐Catalyzed Synthesis of Phenols Employing Hydroxide Salts
Author(s) -
Tlili Anis,
Xia Ning,
Monnier Florian,
Taillefer Marc
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903639
Subject(s) - hydroxylation , catalysis , chemistry , phenols , copper , hydroxide , organic chemistry , solvent , ether , aryl , combinatorial chemistry , alkyl , enzyme
Cheap and cheerful : The direct copper‐catalyzed hydroxylation of activated and unactivated aryl iodides or bromides has been achieved using metal hydroxide salts (MOH). Selective hydroxylation in a H 2 O/co‐solvent system avoids formation of the related biaryl ether by‐product and the low cost of the copper catalytic system makes this method very competitive.