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Infrared Photoactivation Reduces Peptide Folding and Hydrogen‐Atom Migration following ETD Tandem Mass Spectrometry
Author(s) -
Ledvina Aaron R.,
McAlister Graeme C.,
Gardner Myles W.,
Smith Suncerae I.,
Madsen James A.,
Schwartz Jae C.,
Stafford George C.,
Syka John E. P.,
Brodbelt Jennifer S.,
Coon Joshua J.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903557
Subject(s) - mass spectrometry , tandem mass spectrometry , chemistry , peptide , hydrogen atom , tandem , folding (dsp implementation) , hydrogen , infrared , photochemistry , materials science , chromatography , biochemistry , physics , optics , group (periodic table) , organic chemistry , electrical engineering , composite material , engineering
Peptides see the light : The photoactivation of peptide precursor cations during electron transfer dissociation (ETD) led to the generation of isotopic cluster peaks that more closely resembled theoretically predicted product‐ion distributions. This method should enable the application of ETD to low‐charge‐density peptide precursors, the gas‐phase secondary structure of which prevents the direct formation of c ‐ and z . ‐type fragment ions.