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Imparting Multivalency to a Bifunctional Chelator: A Scaffold Design for Targeted PET Imaging Probes
Author(s) -
Liu Wei,
Hao Guiyang,
Long Michael A.,
Anthony Tiffani,
Hsieh JerTsong,
Sun Xiankai
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903556
Subject(s) - bivalent (engine) , bifunctional , scaffold , in vivo , presentation (obstetrics) , chemistry , computer science , combinatorial chemistry , nanotechnology , pet imaging , chelation , molecular imaging , computational biology , materials science , nuclear medicine , positron emission tomography , medicine , biochemistry , programming language , biology , metal , organic chemistry , radiology , microbiology and biotechnology , catalysis
Two are better than one : Multivalent scaffolds for targeted PET imaging probes not only feature chelators that form stable and neutral complexes with a radiometal but also contain functional groups for presentation of multiple targeting molecules. A bivalent scaffold was synthesized and coupled with a targeting ligand to afford the probe, which was used to efficiently image tumors in vivo (see picture).