Rhodium/N‐Heterocyclic Carbene Catalyzed Direct Intermolecular Arylation of sp 2  and sp 3  CH Bonds with Chelation Assistance | Zendy

Kim Min | Zendy; Kwak Jaesung | Zendy; Chang Sukbok | Zendy

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Rhodium/N‐Heterocyclic Carbene Catalyzed Direct Intermolecular Arylation of sp 2 and sp 3 CH Bonds with Chelation Assistance

Author(s) -

Kim Min,

Kwak Jaesung,

Chang Sukbok

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200903500

Subject(s) - carbene , imes , rhodium , catalysis , phosphine , aryl , chemistry , intermolecular force , medicinal chemistry , chelation , alkyl , polymer chemistry , combinatorial chemistry , organic chemistry , molecule

Rh‐oadies join in : A new rhodium catalyst was developed for the chelation‐assisted direct intermolecular arylation using an N‐heterocyclic carbene and phosphine ligands (see scheme; IMes=1,3‐bis(2,4,6‐trimethylphenyl)imidazol‐2‐ylidene). The reaction is operationally simple, proceeds under mild reaction conditions to afford mono‐ or diarylated products in excellent yields, and is applicable to the arylation at the sp 3 or sp 2 CH bonds of 2‐pyridyl‐containing aryl, vinyl, or alkyl moieties.

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