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Rhodium/N‐Heterocyclic Carbene Catalyzed Direct Intermolecular Arylation of sp 2 and sp 3 CH Bonds with Chelation Assistance
Author(s) -
Kim Min,
Kwak Jaesung,
Chang Sukbok
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903500
Subject(s) - carbene , imes , rhodium , catalysis , phosphine , aryl , chemistry , intermolecular force , medicinal chemistry , chelation , alkyl , polymer chemistry , combinatorial chemistry , organic chemistry , molecule
Rh‐oadies join in : A new rhodium catalyst was developed for the chelation‐assisted direct intermolecular arylation using an N‐heterocyclic carbene and phosphine ligands (see scheme; IMes=1,3‐bis(2,4,6‐trimethylphenyl)imidazol‐2‐ylidene). The reaction is operationally simple, proceeds under mild reaction conditions to afford mono‐ or diarylated products in excellent yields, and is applicable to the arylation at the sp 3 or sp 2 CH bonds of 2‐pyridyl‐containing aryl, vinyl, or alkyl moieties.