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Highly Convergent Synthesis of Peluroside A
Author(s) -
Floreancig Paul E.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903480
Subject(s) - aldol reaction , convergent synthesis , chemistry , retrosynthetic analysis , combinatorial chemistry , stereochemistry , total synthesis , organic chemistry , catalysis
When quality and quantity both count : Fragments were coupled through aldol reactions in a highly convergent synthesis of the microtubule‐binding agent peluroside A ( 1 ; see retrosynthetic analysis). The approach is amenable to the preparation of analogues and to the synthesis of suitable quantities of material for biological studies. X c =benzyloxazolidinone, MOM=methoxymethyl, TBS= tert ‐butyldimethylsilyl, Bn=benzyl, TES=triethylsilyl, PMB= p ‐methoxybenzyl.