Premium
Asymmetric Construction of Polycyclic Indoles through Olefin Cross‐Metathesis/Intramolecular Friedel–Crafts Alkylation under Sequential Catalysis
Author(s) -
Cai Quan,
Zhao ZhuoAn,
You ShuLi
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903462
Subject(s) - friedel–crafts reaction , intramolecular force , alkylation , olefin fiber , chemistry , catalysis , olefin metathesis , metathesis , combinatorial chemistry , cascade , organic chemistry , polymerization , polymer , chromatography
A synthetic shortcut : A highly efficient cascade reaction (see scheme) led to polycyclic indoles with excellent enantioselectivity. The combination of the two steps through sequential catalysis enables the use of more readily available starting materials and makes the synthesis more practical. Boc= tert ‐butoxycarbonyl.