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Specificity and Mechanism of Acinetobacter baumanii Nicotinamidase: Implications for Activation of the Front‐Line Tuberculosis Drug Pyrazinamide
Author(s) -
Fyfe Paul K.,
Rao Vincenzo A.,
Zemla Aleksandra,
Cameron Scott,
Hunter William N.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903407
Subject(s) - pyrazinamide , mechanism (biology) , tuberculosis , drug , chemistry , computational biology , mycobacterium tuberculosis , biology , medicine , pharmacology , philosophy , epistemology , pathology
TB or not TB active : The high‐resolution crystal structures (see picture) of the zinc‐containing metalloenzyme nicotinamidase in complex with nicotinic acid and pyrazinoic acid reveal new aspects of enzyme mechanism that help to explain the activation of a front‐line anti‐tuberculosis (TB) drug.