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Boron Mimetics: 1,2‐Dihydro‐1,2‐azaborines Bind inside a Nonpolar Cavity of T4 Lysozyme
Author(s) -
Liu Lijun,
Marwitz Adam J. V.,
Matthews Brian W.,
Liu ShihYuan
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903390
Subject(s) - lysozyme , boron , chemistry , resolution (logic) , enzyme , biochemistry , combinatorial chemistry , stereochemistry , crystallography , computational biology , computer science , biology , organic chemistry , artificial intelligence
Enzymes BN tricked : High‐resolution protein crystallography indicates that unnatural 1,2‐dihydro‐1,2‐azaborines bind inside the nonpolar cavity of T4 lysozyme L99A (see picture) in a fashion that is very similar to the binding of their “natural” all‐carbon isosteres. These studies show that 1,2‐azaborines can serve as boron‐containing, hydrophobic arene mimics in biomedical research.