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A Concise Ring‐Expansion Route to the Compact Core of Platensimycin
Author(s) -
McGrath Nicholas A.,
Bartlett Emily S.,
Sittihan Satapanawat,
Njardarson Jon T.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903347
Subject(s) - chemistry , library science , computer science
Oxatropanes from oxiranes : An expedient assembly of the compact platensimycin core is described. The synthetic approach relies on a Suzuki cross‐coupling, a late‐stage dearomatization reaction, and a copper‐catalyzed vinyl oxirane ring expansion for accessing the oxatropane moiety of the natural product.