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Binaphthyl‐DNA: Stacking and Fluorescence of a Nonplanar Aromatic Base Surrogate in DNA
Author(s) -
Hainke Sven,
Seitz Oliver
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903194
Subject(s) - stacking , dna , base pair , quenching (fluorescence) , duplex (building) , hinge , fluorescence , chemistry , crystallography , computer science , information retrieval , stereochemistry , computational biology , biology , physics , biochemistry , optics , organic chemistry , classical mechanics
A flexible hinge allows multiple binaphthyl‐modified bases to stabilize DNA duplexes through both intrahelical and extrahelical stacking interactions. Two successive binaphthyl pairs stabilize the duplex structure as efficiently as two successive AT pairs. The stacking of these binaphthyl bases in DNA does not lead to self‐quenching of fluorescence.