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Enantioselective Synthesis of Indanols from tert ‐Cyclobutanols Using a Rhodium‐Catalyzed CC/CH Activation Sequence
Author(s) -
Seiser Tobias,
Roth Olivia A.,
Cramer Nicolai
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903189
Subject(s) - rhodium , enantioselective synthesis , catalysis , aryl , chemistry , sequence (biology) , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , alkyl
Activation! An enantioselective activation of tert ‐cyclobutanols by a chiral rhodium(I) complex has been developed. The resulting reactive organometallic species lead (presumably by a CH activation pathway) to aryl rhodium intermediates that provide substituted indanol derivatives in excellent enantio‐ and diastereoselectivities (see scheme).