Biomimetic Nanocarrier for Direct Cytosolic Drug Delivery | Zendy

Zhang Zhihong | Zendy; Cao Weiguo | Zendy; Jin Honglin | Zendy; Lovell Jonathan F. | Zendy; Yang Mi | Zendy; Ding Lili | Zendy; Chen Juan | Zendy; Corbin Ian | Zendy; Luo Qingming | Zendy; Zheng Gang | Zendy

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Biomimetic Nanocarrier for Direct Cytosolic Drug Delivery

Author(s) -

Zhang Zhihong,

Cao Weiguo,

Jin Honglin,

Lovell Jonathan F.,

Yang Mi,

Ding Lili,

Chen Juan,

Corbin Ian,

Luo Qingming,

Zheng Gang

Publication year - 2009

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200903112

Subject(s) - nanocarriers , cytosol , schematic , chemistry , scavenger , phospholipid , drug delivery , computer science , biophysics , nanotechnology , membrane , biochemistry , biology , materials science , engineering , radical , electronic engineering , enzyme

Getting straight to the point : A peptide–phospholipid‐based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non‐endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR‐BI; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR‐BI‐positive cells (nuclei: blue, membranes: cyan).

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