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Biomimetic Nanocarrier for Direct Cytosolic Drug Delivery
Author(s) -
Zhang Zhihong,
Cao Weiguo,
Jin Honglin,
Lovell Jonathan F.,
Yang Mi,
Ding Lili,
Chen Juan,
Corbin Ian,
Luo Qingming,
Zheng Gang
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903112
Subject(s) - nanocarriers , cytosol , schematic , chemistry , scavenger , phospholipid , drug delivery , computer science , biophysics , nanotechnology , membrane , biochemistry , biology , materials science , engineering , radical , electronic engineering , enzyme
Getting straight to the point : A peptide–phospholipid‐based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non‐endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR‐BI; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR‐BI‐positive cells (nuclei: blue, membranes: cyan).