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A Synthetic Lectin for β‐Glucosyl
Author(s) -
Barwell Nicholas P.,
Crump Matthew P.,
Davis Anthony P.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903104
Subject(s) - preference , lectin , alkoxy group , binding affinities , chemistry , carbohydrate , receptor , affinities , biochemistry , computer science , combinatorial chemistry , computational biology , food science , organic chemistry , biology , economics , microeconomics , alkyl
Evolving tastes : Addition of alkoxy groups (green; see picture) to macrotricyclic carbohydrate receptors yields improved affinities and new selectivities. Notably, the propoxy‐substituted receptor shows a strong preference for β‐glucosyl. Glucose is bound both in water and reconstituted blood plasma, which holds promise for applications in blood glucose monitoring.