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Plagiarizing Proteins: Enhancing Efficiency in Asymmetric Hydrogen‐Bonding Catalysis through Positive Cooperativity
Author(s) -
Jones Christopher R.,
Dan Pantoş G.,
Morrison Angus J.,
Smith Martin D.
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903063
Subject(s) - cooperativity , thiourea , intramolecular force , catalysis , hydrogen bond , chemistry , twist , ligand (biochemistry) , combinatorial chemistry , stereochemistry , receptor , organic chemistry , biochemistry , molecule , mathematics , geometry
A new twist for a fold : Conformationally well‐defined thiourea catalysts, like that shown, stabilized by intramolecular hydrogen bonds demonstrate cooperative ligand–receptor binding. This conformation leads to significantly enhanced catalytic efficiency, resulting in higher turnover rates and lower catalyst loading whilst maintaining high enantioselectivity in a model reaction.