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The Continuous‐Flow Synthesis of Ibuprofen
Author(s) -
Bogdan Andrew R.,
Poe Sarah L.,
Kubis Daniel C.,
Broadwater Steven J.,
McQuade D. Tyler
Publication year - 2009
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200903055
Subject(s) - ibuprofen , continuous flow , medicine , mechanics , pharmacology , physics
Let relief flow forth! A three‐step, continuous‐flow synthesis of ibuprofen was accomplished using a simplified microreactor. By designing a synthesis in which excess reagents and byproducts are compatible with downstream reactions, no intermediate purification or isolation steps are required.